Is it Safe to Take CBD with Other Medications? CBD Drug Interactions Explained

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Aaron Cadena

Aaron Cadena

Apr 8, 2019 · 5 min read

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How CBD Interacts with Drugs and Medication

CBD can reduce or increase the effects of certain prescribed medications by interacting with receptors throughout the body’s Endocannabinoid System (ECS) and by inhibiting the activity of cytochrome P450.

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Interaction Between CBD and Drugs that Increase Risk of Bleeding

Studies have shown that CBD and other plant cannabinoids can increase the effects of drugs used for blood-thinning (e.g. warfarin) or drugs with a risk of blood-thinning (e.g. ibuprofen).

Interaction Between CBD and Sedatives

By interacting with neurotransmitter receptors in the central nervous system, cannabinoids like CBD and THC can induce sedative effects on the user. While the sedative effects of THC are associated with drowsiness and lethargy, CBD induces sedative effects that are calming and wake-inducing.

How CBD Interacts Anti-Seizure Medication

While CBD is widely known to be an effective treatment for epileptic seizures, without medical supervision, CBD can present problems under certain circumstances with anti-seizure medication.

Interaction Between CBD and Chemotherapy Drugs

The interaction between CBD and chemotherapy treatment presents a similar situation.

Try the Grapefruit Comparison

Grapefruit juice interacts with drugs in the same way that CBD does — by inhibiting the cytochrome p450 enzymes. The difference is that grapefruit juice is more commonly referenced on medication labels.

  • amiodarone
  • atorvastatin
  • carbamazepine
  • cilostazol
  • clarithromycin
  • colchicine
  • dronedarone
  • erythromycin
  • felodipine
  • fentanyl
  • fentanyl transdermal system
  • fexofenadine
  • indinavir
  • loratadine
  • losartan

It is highly recommended to consult with your physician before taking Cannabidiol if you currently use any other medications…

Consult a Doctor Regarding CBD Drug Interactions

In conclusion, CBD can deliver a wide variety of benefits; however, like any other substance, it can interact with other substances, and it is extremely important to be aware of these CBD drug interactions.

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